Product name: Renin
EC number: EC 3.4.23
Product Description:
Renin , also known as Angiotensinogenase, is a circulating enzyme that participates in the body's renin-angiotensin system （RAS） that mediates extracellular volume （i.e. that of the blood plasma, lymph and interstitial fluid）,and arterial vasoconstriction. Thus it regulates the body's mean arterial blood pressure.
Function:
Renin activates the renin-angiotensin system by cleaving angiotensinogen, produced by the liver, to yield angiotensin I, which is further converted into angiotensin II by ACE, the angiotensin-converting enzyme primarily within the capillaries of the lungs. Angiotensin II then constricts blood vessels, increases the secretion of ADH and aldosterone, and stimulates the hypothalamus to activate the thirst reflex, each leading to an increase in blood pressure.
